Superwarfarin (Brodifacoum) Poisoning

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Secondary and Tertiary Poisoning Risks Associated with Brodifacoum

The field use of brodifacoum baits (Talon® and Pestoff®) to control brushtail possums (Trichosurus vulpecula) has increased in recent years. This has raised concerns of secondary and tertiary poisoning, resulting from the transfer of this toxicant through the food chain. In New Zealand, feral pigs (Sus scrofa) are known to scavenge possum carcasses and may also gain access to bait stations cont...

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A 44-year-old woman with hematemesis and cutaneous hemorrhages as a result of superwarfarin poisoning.

The authors present the case of a 44-year-old American Indian woman with hematemesis, spontaneous cutaneous hemorrhages, and multiple ecchymoses. Coagulation factor analyses demonstrated both prolonged prothrombin time (PT, >40 s) and prolonged partial thromboplastin time (PTT, >120 s). Measurement of the serum level of brodifacoum (37 ng/mL), one of the superwarfarin agents commonly used in ro...

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A Case of Superwarfarin Poisoning Due to Repetitive Occupational Dermal Rodenticide Exposure in a Worker

Superwarfarin poisoning is usually due to chronic occult small-dose exposures and can easily be misdiagnosed and may lead to serious complications. The diagnosis can be confirmed by a concordant history and analyses of blood and urine specimens with the liquid chromatography with tandem mass spectrometry (LC-MS/MS) technique. Several months of continuous treatment with high doses of daily oral ...

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The Persistence and Secondary Poisoning Risks of Sodium Monofluoroacetate (1080), Brodifacoum, and Cholecalciferol In Possums

To determine the risk of secondary poisoning for animals preying on sub-lethally poisoned brushtail possums, captive possums were treated with near-lethal doses of sodium monofluoroacetate (1080) or brodifacoum, and toxicant concentrations in blood and tissue were monitored over time. Sodium monofluoroacetate was rapidly eliminated from the blood (within three days). Brodifacoum was retained in...

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Superwarfarin intoxication of unknown etiology accompanying hemoperitoneum in a patient on fluconazole therapy.

We report a case of brodifacoum (superwarfarin) intoxication of unknown etiology presenting as hemoperitoneum after fluconazole administration for one week before the onset of symptoms. The initial prothrombin time (PT) and partial thromboplastin time (PTT) were markedly prolonged, although a mixing study with normal plasma showed that the corrected PT and PTT were in the normal range. Vitamin ...

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ژورنال

عنوان ژورنال: Anaesthesia and Intensive Care

سال: 1997

ISSN: 0310-057X,1448-0271

DOI: 10.1177/0310057x9702500622